DRUG DATABASE

Duration: ~2–6 hours (effects may persist longer depending on dose).

Onset: ~5–15 minutes after consumption.

Drug Class: Depressant.

Mechanism: Primarily enhances GABA activity and suppresses glutamate signaling, resulting in reduced central nervous system activity.

Common Effects: Relaxation, reduced social anxiety, lowered inhibitions, mood elevation, impaired judgment, and slowed reaction time.

Physical Effects: Impaired coordination, slurred speech, reduced balance, nausea, dehydration, flushing, and drowsiness.

Psychological Effects: Increased sociability, emotional amplification, impaired decision-making, and memory disruption.

Risks: Accidents, alcohol poisoning, blackouts, aggressive behavior, respiratory depression at high doses, and dangerous interactions with other depressants.

Dependence Potential: High with frequent use. Physical dependence and withdrawal can develop.

Withdrawal: Anxiety, tremors, insomnia, sweating, elevated heart rate, seizures, and delirium tremens in severe cases.

Overdose Risk: High. Severe alcohol poisoning can result in coma, respiratory failure, or death.

Duration: ~1–4 hours when smoked; 4–12+ hours for edibles.

Onset: Seconds to minutes when inhaled; 30–120 minutes when eaten.

Drug Class: Cannabinoid.

Mechanism: THC primarily activates CB1 cannabinoid receptors throughout the brain and nervous system.

Common Effects: Relaxation, euphoria, altered sensory perception, increased appetite, and changes in time perception.

Physical Effects: Dry mouth, red eyes, increased heart rate, muscle relaxation, and altered coordination.

Psychological Effects: Enhanced sensory appreciation, introspection, altered thought patterns, and short-term memory impairment.

Risks: Anxiety, paranoia, panic reactions, impaired driving ability, and temporary cognitive impairment.

Dependence Potential: Moderate. Regular use can lead to cannabis use disorder in some individuals.

Withdrawal: Irritability, sleep disturbance, reduced appetite, mood changes, and cravings.

Overdose Risk: Extremely low risk of fatal overdose, though excessive consumption can cause severe anxiety, confusion, or distress.

Duration: ~15–60 minutes.

Onset: Seconds to minutes depending on route of administration.

Drug Class: Stimulant.

Mechanism: Blocks reuptake of dopamine, norepinephrine, and serotonin, increasing their concentration in the brain.

Common Effects: Intense euphoria, alertness, confidence, increased energy, and reduced fatigue.

Physical Effects: Elevated heart rate, increased blood pressure, dilated pupils, reduced appetite, and increased body temperature.

Psychological Effects: Heightened confidence, talkativeness, impulsivity, and increased focus.

Risks: Cardiac arrhythmias, stroke, heart attack, seizures, paranoia, panic, and compulsive redosing.

Dependence Potential: High due to strong reinforcement of reward pathways.

Withdrawal: Fatigue, depression, increased sleep, cravings, and reduced motivation.

Overdose Risk: High. Cardiovascular complications are a major cause of fatal overdose.

Duration: ~5–20 minutes when vaporized; longer when combined with MAOIs.

Onset: Seconds when inhaled.

Drug Class: Psychedelic (Tryptamine).

Mechanism: Primarily acts as an agonist at serotonin 5-HT2A receptors.

Common Effects: Intense visual phenomena, altered sense of self, changes in perception of reality, and immersive internal experiences.

Physical Effects: Increased heart rate, elevated blood pressure, pupil dilation, and body sensations that vary widely between individuals.

Psychological Effects: Ego dissolution, profound emotional experiences, altered perception of time, and vivid imagery.

Risks: Psychological distress, panic reactions, confusion, and increased risk of injury in unsafe environments.

Dependence Potential: Considered very low.

Tolerance: Rapid tolerance develops but generally dissipates quickly.

Overdose Risk: Fatal overdose appears rare, though behavioral and psychological risks remain significant.

Duration: ~8–12 hours, with residual effects sometimes lasting longer.

Onset: ~20–90 minutes.

Drug Class: Psychedelic (Lysergamide).

Mechanism: Strongly influences serotonin receptors, particularly 5-HT2A.

Common Effects: Visual patterning, enhanced sensory perception, altered thinking, emotional amplification, and changes in time perception.

Physical Effects: Dilated pupils, elevated heart rate, mild stimulation, increased energy, and reduced appetite.

Psychological Effects: Introspection, altered cognition, enhanced creativity, profound emotional experiences, and altered sense of self.

Risks: Anxiety, panic, confusion, dangerous decision-making, and rare persistent perceptual disturbances.

Dependence Potential: Very low.

Tolerance: Rapid tolerance develops after repeated use.

Overdose Risk: Direct fatal toxicity appears very low, though accidents and psychological crises may occur.

Duration: ~4–6 hours with after-effects lasting longer.

Onset: ~20–60 minutes.

Drug Class: Empathogen / Stimulant.

Mechanism: Causes substantial release of serotonin, dopamine, and norepinephrine.

Common Effects: Euphoria, empathy, emotional openness, sociability, and enhanced appreciation of music.

Physical Effects: Increased heart rate, jaw clenching, sweating, elevated body temperature, and pupil dilation.

Psychological Effects: Increased trust, emotional closeness, enhanced mood, and reduced fear response.

Risks: Hyperthermia, dehydration, excessive water intake, cardiovascular stress, and post-use mood reduction.

Dependence Potential: Moderate psychological dependence potential.

After Effects: Fatigue, low mood, irritability, and sleep disruption may occur for several days.

Overdose Risk: Moderate. High doses can cause dangerous overheating, cardiovascular complications, and serotonin toxicity.

Duration: ~45–120 minutes.

Onset: Seconds to minutes depending on route of administration.

Drug Class: Dissociative Anesthetic.

Mechanism: Primarily blocks NMDA glutamate receptors, disrupting normal sensory integration.

Common Effects: Dissociation, altered perception, dream-like states, and detachment from surroundings.

Physical Effects: Reduced coordination, numbness, dizziness, slurred speech, and impaired balance.

Psychological Effects: Detachment from body, altered sense of identity, and unusual thought patterns.

Risks: Falls, accidents, confusion, unconsciousness at high doses, and bladder complications with chronic heavy use.

Dependence Potential: Moderate psychological dependence potential.

Long-Term Concerns: Frequent heavy use has been associated with urinary tract and bladder damage.

Overdose Risk: Lower than many depressants when used alone, but significantly increased when combined with alcohol or other sedatives.

Duration: ~4–8 hours.

Onset: ~20–60 minutes.

Drug Class: Psychedelic (Tryptamine).

Mechanism: Converted into psilocin, which primarily activates serotonin 5-HT2A receptors.

Common Effects: Visual distortions, emotional shifts, altered perception of time, introspection, and sensory enhancement.

Physical Effects: Dilated pupils, mild nausea, increased heart rate, and changes in body sensation.

Psychological Effects: Emotional amplification, increased introspection, spiritual experiences, and altered thought patterns.

Risks: Anxiety, panic, confusion, difficult experiences, and unsafe behavior in uncontrolled environments.

Dependence Potential: Very low.

Tolerance: Rapid tolerance develops after use and typically resolves within several days.

Overdose Risk: Fatal toxicity appears extremely low, though psychological distress can become severe.